Society of Toxicology - Annual Meeting 2. Share this page. Featured Sessions. Daily Plenary Session: Data Science.

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Monday, March 1. 3, 8: 0. AM to 9: 2. 0 AMView this Plenary Presentation  Systems Approaches to Drug Efficacy and Toxicity in an Era of Big Data. Lecturer: Peter Sorger, Harvard Medical School, Boston, MA. The development of new therapeutic drugs is fundamental to improving human health, but the process is challenged by rising costs and a high rate of failure. New and better technology and big data are often put forward as the solutions to these problems. However, I will discuss laboratory and clinical studies showing that some of the fundamental concepts in pharmacology and toxicology are ripe for reinvention.

Increasing data on the impact of cell- to- cell variability and temporal variation in cellular physiology motivates new ways of thinking about seemingly simple concepts such as drug dose- response. Better understanding of sources of variation in laboratory and clinical data should also improve our ability to identify robust biomarkers of therapeutic and adverse effects.

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I will argue that big data and data science are essential but insufficient: correct interpretation of empirical data in biomedicine hinges on theories about mechanism. I will discuss these theories, with reference to cytotoxic and targeted anti- cancer therapies, and studies of drug response in cell culture, animal models, and human clinical trials.

New pharmacological principles derived from such studies are being developed into practical algorithms and open- source software as a means to improve target qualification, lead molecule optimization, and early phase clinical trials. The hoped for outcome: better drugs at a cost society can afford. Open Ecosystems for Understanding Toxicities and Adverse Events.

Lecturer: Lara Mangravite, Sage Bionetworks, Seattle, WA. This will include the use of remote sensor- based data collection approaches to capture fluctuations in health relative to medication and disease—and the consideration of how these could be used to track adverse events. Cohen, University of Nebraska Medical Center, Omaha, NE. Cancer develops because of multiple permanent genetic errors arising in a single stem cell, a clonal disease. Every time DNA replicates, spontaneous mistakes can occur.

Thus, the risk of cancer can be increased by either directly damaging DNA each time it replicates (DNA reactive) or increasing the number of DNA replications (cell proliferation), or both. Some have indicated that the “spontaneous” errors that occur during DNA replication are the basis for cancer being due to “bad luck,” and are the cause of most cancers. However, it is well- known that numerous environmental factors can increase the risk of cancer. This dilemma is readily resolved by realizing that the number of stem cells and the rate of their proliferation can be markedly influenced by the environment. Over the course of more than a 5. I have been actively involved in research on DNA reactive carcinogens (nitrofurans, aromatic amines, nitrosamines) and non- DNA reactive carcinogens (saccharin, PPAR. Based on the fundamentals of carcinogenesis, a mode of action (MOA) approach, and the accumulated knowledge of carcinogenesis in animals and humans, carcinogenic risk can be readily evaluated today without utilizing the two- year bioassay.

Meet the Directors: A Conversation with Linda S. Birnbaum and Robert J. Kavlock. Monday, March 1. PM to 2: 3. 0 PMChairperson(s): Patricia E. Ganey, Society of Toxicology Vice President; Michigan State University, East Lansing, MI. Panelists: Linda S. Birnbaum, NIEHS, Research Triangle Park, NC; and Robert J.

Kavlock, US EPA, Washington, DC. This important session will provide an informal venue for meeting attendees to have a candid and open discussion with two key leaders of federal organizations with missions to protect and improve public health: Dr. Birnbaum, Director, National Institute of Environmental Health Sciences (NIEHS), NIH, and Dr. Kavlock, Deputy Assistant Administrator for Science at the Office of Research and Development for the US EPA. The entire session will be devoted to a question- and- answer format concerning scientific directions and priorities for NIEHS and EPA including funding priorities and outlooks, and training opportunities.

SOT/EUROTOX Debate. Monday, March 1. 3, 4: 4. PM to 6: 0. 0 PMToxicology Testing of Drug Combinations Does Not Add Significant Value to Human Risk Evaluation Beyond What Is Known for the Individual Agents. Chairperson(s): Leigh Ann Burns Naas, Gilead Sciences Inc., Foster City, CA; and Heather Wallace, University of Aberdeen, Aberdeen, United Kingdom. SOT Debater: Kenneth L. Hastings, Hastings Toxicology Consulting LLC, Mount Airy, MD.

EUROTOX Debater: Phil Bentley, Toxicodynamix International LLC, Hendersonville, NC, and Basel, Switzerland. Endorser(s): Society of Toxicology (SOT)European Societies of Toxicology (EUROTOX)Each year the SOT Annual Meeting includes a debate that continues a tradition that originated in the early 1. This year, our debaters will address the proposition: Toxicology Testing of Drug Combinations Does Not Add Significant Value to Human Risk Evaluation Beyond What is Known for the Individual Agents.

The use of innovative drug combinations—both large and small molecule—in clinical development is increasing. The objective is often to increase efficacy by targeting multiple pathways for the same disease, to improve safety by being able to lower doses of one or more drugs, or to provide more convenient/acceptable therapies to patients. As the number of these clinical combinations rises, there is an increasing need to evaluate their nonclinical safety. At the heart of this evaluation is the question regarding the need for actual animal testing. Global regulatory guidance has provided a framework for the nonclinical safety evaluation of combination products, which considers the need for testing based on such things as the potential for PK or PD interactions, overlapping toxicology profiles, extent of toxicology characterization of the individual agents and their margins of safety, human clinical experience with the individual agents, and the stage of clinical development of each agent. The guidance applies not only to fixed dose combinations but co- packaged and co- use as well.

Unless there is clinical experience with the combination and that combination involves two late stage (Phase 3, Marketed) entities, nonclinical repeat dose toxicity studies up to 9. This broad recommendation is inconsistent with the principles of the 3. Rs for reduction, refinement, and replacement in animal experimentation. The debaters will discuss the evidence regarding whether the information gathered in nonclinical combination studies provides clear benefit in the overall risk evaluation for clinical combinations. Regardless of framework differences and personal convictions, each scientific debate delegate will present relevant evidence and compelling scientific arguments to persuade and appeal to the audience in order to obtain the approval or rejection of the motion. In addition to being a featured session at the SOT Annual Meeting in Baltimore, Maryland, this debate will again take place (with the debaters taking the reverse positions) in Bratislava, Slovak Republic, during the 5. Congress of the European Societies of Toxicology (2.

EUROTOX Annual Congress), September 1. Daily Plenary Session: Precision Medicine.

Tuesday, March 1. AM to 9: 2. 0 AMView this Plenary Presentation  Pharmacogenomics of Drug Toxicity in Cancer: Making the Case for Precision Medicine. Lecturer: Jun J. Jude Children’s Research Hospital, Memphis, TN. This is particularly relevant in cancer where chemotherapy is often associated with severe acute toxicities and debilitating long- term side effects.

Therefore, the narrow therapeutic index of anti- leukemic drugs provides a compelling rationale for improvements in evidence- based precision medicine approaches.

The 3. 7 Albums We’re Ready to Stream on Loop in 2. After a 2. 01. 6 overstuffed with year- round releases from such acts as Beyonc?

The easy answer is yes, obviously: Taylor Swift, who despite being on a self- imposed hiatus, won’t likely lay low for much longer. But the better answer: Taylor Swift plus every other artist, big or small, who stayed relatively off the grid last year while the the rest of the industry fried it. Though Run the Jewels already jumped the gun and snuck in ahead of schedule, there are still plenty of albums from artists both new and familiar to get excited about in 2. The music industry being what it is, this list incorporates speculation, rumor, and hearsay — and despite all that, there’s a good chance that the albums we never even saw coming will make the loudest noise. Flaming Lips, Oczy Mlody (January 1. Surprise surprise: The new Flaming Lips album is going to be trippy as hell. Front man Wayne Coyne, whose birthday also falls on the LP’s release date, described it as sounding like A$AP Rocky and Pink Floyd’s Syd Barrett getting trapped in a fairy tale together.

And in this fairy tale, Oczy Mlody is a party drug that leads to bliss and orgies. The first taste of this adventure is “The Castle,” while the album’s closer, “We a Family,” features Coyne’s good pal Miley Cyrus.

They haven’t fully departed from the sparse indie- pop sounds that made them famous, but new tunes like “Say Something Loving” and the Hall and Oates–sampling “On Hold” are much more uplifting and upbeat than their older material. Before the (relative) optimism of the new year fades, we welcome the xx’s not- so- dour return. In the shadow of a lengthy press cycle for BET’s forthcoming three- night New Edition biopic event, a new BBD album titled Three Stripes will be released. Ronnie, Ricky, and Mike haven’t really recorded together since a 2. New Edition reunion, and their last full length as a trio came out way back in 2. Run” is solid proof they’ve evolved from teen heartthrobs into wizened, dancing uncles in style.

Though the years since then have been filled with music from new bands with similar sensibilities, those groups have largely served as stopgaps until Japandroids could make their triumphant return. If the band’s string of insane live shows, in which they played new material, are any indication, 2. She was nominated for a Grammy for 2. You Should Be Here, a mixtape that once again reconsidered the format; now she’ll release her proper debut album at the top of the year. Kehlani had, to put it mildly, a difficult 2. Her album, which has long been in the works, will likely extend the frank discussion about mental health that Kehlani started in her music years ago.

But judging from the self- assured, sex- driven songs she’s sprinkled among her new releases, it won’t all be so heavy. Stefon Alexander, announced that he had to undergo a kidney transplant, forcing the cancellation of his upcoming tour. After recovering from the operation and recording another album with the seven- member Minneapolis hip- hop collective Doomtree, Stef turned his attention back to solo work, making a statement return with “sleepdrone/superposition,” a nearly nine- minute destroyer featuring Bikini Kill’s Kathleen Hanna, Lizzo, Allan Kingdom, and Astronautalis, plus his oldest son, Jake. It’s the final track of a dozen on Chill, dummy, which also features collaborations with Justin Vernon, Open Mike Eagle, and Busdriver, among others. Clash N Slash Free Serial Crack Codes. Download Bbm For Tecno D3 Pictures on this page.

It promises a blend of aggression, anarchy, humor, and, at the very least, the best song inspired by The Revenant, “Wearing a Bear.”—DRTy Segall, Ty Segall (January 2. Not even 3. 0, the garage rocker is releasing his ninth solo album and second self- titled LP. This time, Segall recorded it with his band, which includes the extremely talented Mikal Cronin on bass, playing live in the studio, which just happens to be Steve Albini’s famed Electrical Audio.

The lead track, “Orange Color Queen,” is a fuzz- soaked ditty that would feel at home on an early . Though the album features more acoustic- based songs than normal for Ty, it’s a perfect introduction to those who have yet to dive into his vast discography. Then again, Sampha’s always been one to flow at his own pace, unconcerned with how the rest of his big- name collaborators move comparatively. It takes time to harness the kind of devastation that constantly pours out of Sampha through song. Sampha’s music tugs in that way, yanking at your soul until you fall. In 2. 01. 5, his mother died of cancer, and he’s said this album, while not wholly written about her, ended up being how he processed her death.

Grab a few boxes of tissues and join him on this emotional journey. After getting pop music out of his system and going through a bit of soul- searching (and maybe a This Is Us binge), it appears cathartic Ryan is imminent. His new songs sound pained, personal, and ultimately resolute.

Adams has described feeling shattered before this record and that he wrote it to mend himself back together. This record mattered more to me than any record before it and my life depended on making it.

I would have died inside if I hadn’t,” he recently said. It’s hope for anybody who’s forgotten what that is.” And, really, that’s all we’ve ever asked of a Ryan Adams album. The album flopped spectacularly in spite of its great ideas, so the quartet came back in pure pop- country form mere months later with “Better Man,” a massive breakup tune written by Taylor Swift. Fair chance the new album The Breaker will be a solid back- to- basics effort. It’s just too bad they feel like they need to go there again. The lead single “Things” examines the pursuit of money and whether or not it buys peace, all over a dense dance groove. As a Muslim with a Sudanese immigrant father, he surely has a few thoughts to share about the current state of the union, but he deftly uses his own experiences to reflect on the greater state of humanity, in all its beauty and flaws.

So far, he’s released “God Bless Ohio,” a characteristically sardonic rumination on life in the Midwest that’s as cold as a Buckeye State winter. Song Memoir is a five- disc undertaking that dedicates one song to each year of the gifted eccentric’s life, from the frustrated college thinker of “’8. How I Failed Ethics” and the loyal dive- bar drinker of “’0. Be True to Your Bar.” The last time the Magnetic Fields chanced an undertaking this large they came away with the stone- cold indie- pop classic 6. Love Songs. Gargantuan shoes to fill, but ours is a capable cobbler. According to Mercer, who produced the 1.

Beach Boys–like pop, synths, and even country influences, but with the same old kind of downcast vibes that made him a hero among indie introverts. Check out the psychedelic- tinged first single “Dead Alive” for a taste of what’s to come. The Scottish quintet recorded Damageand. Joy with Killing Joke alumnus Youth as producer, and if “Amputation” is any indication, it’ll hew closer to the poppier confections of 1.

JAMC swan song Munki than the tart 1. Psychocandy. Vincent (Spring 2. St. Vincent recently told Guitar World that her next album will be the “deepest, boldest work” she’s ever done, which, if you know Annie Clark’s oeuvre, is really saying something. It’s hard to imagine how it possibly gets bolder than her 2. St. Vincent to take it up a notch. She says this album is heavily influenced by the current political climate and that “only music that has something pretty real to say is gonna cut the mustard.” If the rest of the music biz isn’t already shook, they should be.

With the aim of releasing it just in time for summer, Charli has said it will be her most commercial album yet, split between pop and club- oriented tracks that still feature her flare for getting wild, with producers like SOPHIE, Blood. Pop, and Stargate.